Bisphenol A and related compounds in dental materials.
نویسندگان
چکیده
CONTEXT Dental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties. OBJECTIVES To systematically compile and critically evaluate the literature characterizing BPA content of dental materials; to assess BPA exposures from dental materials and potential health risks; and to develop evidence-based guidance for reducing BPA exposures while promoting oral health. METHODS The extant toxicological literature and material safety data sheets were used as data sources. RESULTS BPA is released from dental resins through salivary enzymatic hydrolysis of BPA derivatives, and BPA is detectable in saliva for up to 3 hours after resin placement. The quantity and duration of systemic BPA absorption is not clear from the available data. Dental products containing the bisphenol A derivative glycidyl dimethacrylate (bis-GMA) are less likely to be hydrolyzed to BPA and have less estrogenicity than those containing bisphenol A dimethacrylate (bis-DMA). Most other BPA derivatives used in dental materials have not been evaluated for estrogenicity. BPA exposure can be reduced by cleaning and rinsing surfaces of sealants and composites immediately after placement. CONCLUSIONS On the basis of the proven benefits of resin-based dental materials and the brevity of BPA exposure, we recommend continued use with strict adherence to precautionary application techniques. Use of these materials should be minimized during pregnancy whenever possible. Manufacturers should be required to report complete information on the chemical composition of dental products and encouraged to develop materials with less estrogenic potential.
منابع مشابه
Bisphenol A and Related Compounds in Dental Materials
CONTEXT: Dental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties. OBJECTIVES: To systematically compile and critically evaluate the literature characterizing BPA content o...
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OBJECTIVES This study investigated the stability of compounds of dental sealant materials in a salivary matrix. METHODS Various amounts of bisphenol A (BPA), bisphenol A dimethacrylate (BIS-DMA) or triethylene-glycol dimethacrylate (TEGDMA) were added to whole salivary samples, and stored at -70 degrees C or -20 degrees C for up to 4 months. In other experiments, four separate whole salivary ...
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Objective: To review scientific literature on BPA in dental materials, introducing the chemistry of BPA and its derivatives, and evaluating the BPA release and exposure from dental materials and the potential human health risks. Materials & methods: A search of English peer-reviewed dental literature from Pub Med and MEDLINE databases was conducted, and the key words included bisphenol A and BP...
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عنوان ژورنال:
- Pediatrics
دوره 126 4 شماره
صفحات -
تاریخ انتشار 2010